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The first study to show efficacy of GLP-1 agonist in patients with preexisting cardiovascular disease and overweight or obese without diabetes

Springer: Berlin, 1996, pp 311326

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Chronic liver disease, uncontrolled diabetes, and severe thyroid dysfunction all alter peptide pharmacokinetics and blunt reproductive response

Mechanistic background: see the overview BPC-157 mechanism and research status in the context of laboratory research and RUO framing

The researchers noted that metformin itself may have cancer-protective properties, which could explain why GLP-1RAs showed limited additional benefit against other cancers in this comparison