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While Vitamin B12 tablets are readily available, easy to use (you just pop it in your mouth!), and cheaper, the rate at which the vitamin absorbs in tablet form is relatively slow

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The cold temperatures of a refrigerator are required to slow down the chemical processes that break down the peptide chain

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Switching routes mid-protocol introduces a confounding variable that can complicate data interpretation, particularly if pharmacokinetic endpoints (Tmax, AUC, Cmax) are being measured