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In a few cases, cleft lip and palate is associated with: the genes a child inherits from their parents (although most cases are a one-off) smoking in pregnancy or drinking alcohol while pregnant obesity during pregnancy a lack of folic acid during pregnancy taking certain medicines in early pregnancy, such as some anti-seizure medicines In some cases, a cleft lip or palate can occur as part of a condition that causes a wider range of birth defects, such as 22q11 deletion syndrome (sometimes called DiGeorge or velocardiofacial syndrome) and Pierre Robin sequence

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Zhang X, Liu J, Bai C, Fan Y, Song H, Huang Z, et al

Garcia-Prez 2013

MEOS uses a different enzyme (Cytochrome P450 2E1 - CYP2E1) to metabolize ethanol, but still creates toxic acetaldehyde

The melatonin synthesis pathway Melatonin production follows a precise biochemical chain