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The transition from weekly injections to monthly maintenance paradigms like MariTide and Pfizers candidate is a massive leap forward for patient compliance and long-term adherence

However, the relationship is indirect and complex

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A study published in Diabetes Obes Metab showed that semaglutide resulted in over a decade of greater reduction of body weight than placebo, lifestyle modification or pharmacotherapy with orlistat after 68 weeks of treatment

Researchers have linked those effects to upregulation of growth factor receptors, including VEGFR2, and to nitric oxide signaling

doi:10.1177/0269881113482532