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The appetite-suppressing effect of pancreatic peptide YY (peptide tyrosine tyrosine) is well known, and initial clinical studies are underway with long-acting YY peptide analogs as monotherapy and in combination with GLP-1 receptor agonists for obesity treatment [115]

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It will require clinical trials by independent entities to delineate the true effectiveness and side effect profile of this and all new medications. Following the results of earlier trials, Novo Nordisk submitted a New Drug Application to the Food and Drug Administration (FDA) in December 2025 for the use of CagriSema to assist and maintain weight loss alongside diet and exercise adjustments

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