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Weeks 5-12: Acceleration Phase Fat loss accelerates significantly during weeks 5-12 as doses increase and the glucagon receptor component reaches full effect

Approximately 2030% of patients on GLP-1 receptor agonists report diminished appetite suppression after 612 months of continuous use

1,4 SUSTAIN 5: add-on basal insulin 1,10 In adult patients with type 2 diabetes on basal insulin metformin Mean change in A1C from baseline at Week 30 Patients with A1C 8% at screening had their background basal insulin dose reduced by 20% at the start of the trial to limit the potential risk of hypoglycemia

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A patient who is always under-recovered is more likely to lose momentum, reduce activity, and see poorer results over time