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[1] The NHS advises that taking up to 2mg (2000 micrograms) per day of vitamin B12 supplements is unlikely to cause harm

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Oral vitamin D supplementation induces cathelicidin production in the skin of atopic dermatitis patients

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By stabilizing the copper-peptide bond and optimizing bioavailability at the dermal level, the Complex ensures the active doesn't degrade before it can act (a common limitation in standard formulations)