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A 2024 study found that GLP-1 peptides directly inhibit the TRPV1 pain receptor, which is sometimes called the chilli pepper receptor because its the one that responds to capsaicin [6]

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Participants were randomized in a 1:1:2 ratio to receive once-weekly retatrutide 9 mg, retatrutide 12 mg, or placebo for 80 weeks, with treatment initiated at 2 mg and gradually escalated every four weeks to the assigned maintenance dose