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Similarly, in male mice, a biogenic immune stressor producing sustained IFN- elevations induced chronic increases in both peripheral and brain IDO activity, accompanied by widespread TRP depletion, indicating that prolonged cytokine signalling drives central and peripheral TRP loss [68]
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Within the TME's boundaries, Treg cells exert control over T cells, NK cells, MDSCs, and macrophages through humoral and intercellular interactions, while also producing molecules like cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), IL-2, IL-10, and TGF-, contributing to the management of immunosuppression [88]
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