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In terms of opioid addiction, several GLP-1RAs have been shown to reduce self-administration and reinstatement of drug-seeking behavior for heroin, fentanyl, and oxycodone in rodent models [73-76]
63 Albiglutide was approved for marketing in the European Union in March 2014 and in the United States in April 2014
A similar conversation is now emerging around obesity medicines: GLP-1 and dual agonists are being recognised internationally as evidence-based treatments for obesity with cardiometabolic benefit.[8] Indian insurers may progressively consider coverage when obesity is severe and linked with diabetes, heart disease, or sleep apnoea, rather than for cosmetic weight loss alone.[10] For families, this could mean negotiating group policies and reading the policy wording carefully to see if medically supervised GLP-1 therapy for obesity-with-complications is covered
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Additional safety considerations include caution in patients with severe gastroparesis, and a potential risk of diabetic retinopathy complications with rapid glucose improvement, particularly with semaglutide
