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Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction: the DELIVER trial [presentation]

Abbreviations: GIP, glucosedependent insulinotropic polypeptide

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Table 10.2 Effects of metformin against insulin resistance syndrome Initial doses (500 mg once a day) must be slowly increased at weekly intervals and administered two or three times a day before or together with meals considering a maximum dose of 2,550 mg/day

In gene knockdown assay, GLP-1R siRNA#1 demonstrated a significant decrease in the levels of GLP-1R mRNA and protein (Supplemental Fig