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Recent studies have observed that cepharanthine is capable of inhibiting the interaction between TSHR.132 (TSH receptor peptide) and HLA-DR1-Arg74, thus blocking T cell activation and cytokine response in a Graves disease-relevant humanized mouse model expressing HLA-DR3 (Li et al

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Researchers working with animal models may also investigate peptide interactions under approved institutional oversight where permitted by applicable regulations

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Mazzone M, Basilico C, Cavassa S, Pennacchietti S, Risio M, Naldini L, Comoglio PM, Michieli P (November 2004)