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The Incretin Concept: From Gut to Glory The story begins with the incretin effectthe observation that glucose taken by mouth triggers a much stronger insulin response by increasing the production of hormones in the pancreas, compared to when it is injected directly into a vein

Forest plot Figure 2 presents the individual effect sizes and their corresponding 95% confidence intervals for each included study, visually illustrating their consistency with the pooled effect estimate

Other companies are exploring different combinations of hormone agonists, different dosing strategies, and oral formulations of dual agonists

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