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Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose

This effect may be related to the promotion of neuronal survival, axonal growth, and synapse formation by Melanotan 2

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Cardiovascular Evidence: SELECT Trial Beyond weight loss, semaglutide demonstrated direct cardiovascular protection in the SELECT trial the largest cardiovascular outcomes trial ever conducted in an obesity population