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This decline correlates with the age-related slowdown of tissue regenerative capacities, which has directed research toward anti-aging and regenerative applications of this peptide

10.1097/01.rlu.0000233148.45744.44 50 ElolaM.YoldiA.EmparanzaJ

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The inactivation of the ferroptosis regulator GPX4, which can upregulate 12/15-ALOX and COX1 expression [92, 93], may accelerate AA metabolism and further promote inflammatory responses