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It is generally believed that the observed mitochondria-related cytoplasmic vesicles result from the lysosomal apoptotic pathway mediated by mitochondria.35 The formed vesicles might also be autophagosomes of mitochondrial origin, which after maturation, fuse with lysosomes.36 It is of note that a similar preferential intracellular co-localization phenomenon was described for phtalo-cyanine, a related porphyrin-like molecule.37 This data are also in line with the results of the functional studies

As such, the applicant requested that CMS reinstate C1831 to ensure a full 3 years of device pass-through payment status and to capture the necessary cost data

Using click chemistry, we incorporated a biotin tag that facilitated streptavidin pulldown of proteins covalently modified by our probes, followed by quantitative mass spectrometry (MS) for target identification

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