Each of the 4 studies on rimonabant showed significant reductions in body weight and waist circumference over a 1 to 2-year period
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In contrast to TMX-treated rats, the protective group treated with LC showed a significant decrease in AchE (51%) and MAO (25%) activity and a significant increase in Ach, DA, and 5-HT levels (117, 84, and 37%, respectively)
Excess adipose tissue is a reservoir of pro-inflammatory cytokines such as TNF- and IL-6, key drivers of RA disease activity