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Furthermore, vascular endothelial injury and endothelial cell dysfunction in PCOS patients are independent of age, body weight, and metabolic abnormalities, suggesting that PCOS may be an independent risk factor for CVDs and could lead to an earlier onset of CVDs despite the presence of metabolic disorders (97, 98).The current consensus is that chronic inflammation of the vascular endothelium and the resulting endothelial dysfunction are fundamental to the pathogenesis of CVDs (99, 100)

Clin Exp Immunol 194:153165

10.1016/j.jep.2023.116556 94 MaoX.LiY.YangR.WeiJ.ZhaoZ.ZhangT.et al (2022)

Immunomodulatory role in anaemia Vitamin D is essential for our bone strength and supports our immune system and its function

Bartosik J, Wulf HC, Kobayasi T

Spatiotemporal single-cell tracking analysis in 3D tissues to reveal heterogeneous cellular response to mechanical stimuli