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in contrast, a high protein test breakfast (enriched with milk-based proteins) or liquid preloads of whey, casein, soy and gluten caused a prolonged suppression of ghrelin.42 The ability of ingested proteins and carbohydrates to cause ghrelin suppression is similar, even if they act with a different kinetic.43 Ghrelin concentrations may both decrease or increase after ingestion of a high-fat meal, with a slower return to baseline than after an ingestion of high-carbohydrate meal.44,45 The effect of fatty acids on ghrelin secretion may be dependent on their chain length.45 In a study, long-chain fatty acids (sodium oleate, 18 carbon atoms) showed to inhibit ghrelin, whereas medium-chain fatty acids (sodium caprylate, 8 carbon atoms) were ineffective.46 Nutrients and CCK release Ingested fats and proteins cause a greater, faster and longer postprandial release of CCK than carbohydrates.47 In fact CCK increase after carbohydrates is short-lived and returns to baseline within 1h.48 Fiber content of the meal also affects postprandial CCK release

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The percentage of animals responding over time receiving Etomoxir, Escitalopram or vehicle was compared (Fig