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A randomized, phase II study evaluated cediranib plus fulvestrant in postmenopausal women with hormone-sensitive metastatic breast cancer compared to placebo ( Proposed Mechanisms for the Failure of Angiogenesis Inhibitors in Breast Cancer Evidence from clinical trials constantly showed disappointing treatment outcomes for targeting VEGF/VEGFR signaling in breast cancer

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Richardson SM, Hughes N, Hunt JA, Freemont AJ, Hoyland JA: Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels

Growth hormone secretagogues: Selective stimulation and metabolic outcomes