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DPP-4i treatment significantly increases proximal tubular cell viability and reduces ROS production

In addition, stem-like features can be acquired de novo by non-CSCs in response to environmental stimuli such as hypoxia, inflammation, or therapeutic pressure, indicating that CSCs may represent a dynamic functional state rather than a static subpopulation

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[DOI] [PubMed] [Google Scholar] Lordan R

These effects may arise from the peptides capacity to modulate local growth factors and attenuate inflammatory pathways