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Lyophilized powder prior to reconstitution should be stored at -20C to preserve long-term stability

Trial dosing follows a stepwise escalation from 12 mg up to maintenance doses of 4 mg, 8 mg, or 12 mg subcutaneously once weekly

Recent national policy efforts around payer coverage for GLP-1s [215,216] have elevated the importance of concurrent coverage for MNT as part of comprehensive lifestyle programming that should accompany GLP-1 treatment

Key Takeaways MOTS-c is a mitochondrial-derived peptide involved in regulating metabolic homeostasis, improving insulin sensitivity, and enhancing mitochondrial function, primarily studied in preclinical models