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Potential for Combination Therapies Medications like tirzepatide combine GLP-1 and GIP agonism for enhanced metabolic benefits

The primary limitation of FAERS is its dependence on voluntary adverse event reporting, which restricts its ability to comprehensively document all occurrences

Safety and Tolerability As with many metabolic therapies, the most commonly reported side effects in the Retatrutide trial included gastrointestinal symptoms such as nausea, diarrhea, constipation, vomiting, and decreased appetite, patterns seen with many gut-hormone modulators