If youre new to the issue, Vegan B12 Deficiency: Putting It into Perspective, and Safest Source of B12 are good places to start

Made in United States Beauty Concerns: Anti-Acne, Anti-Aging, Brightening, Exfoliating, Hydrating, Pore Reducing, Sensitive Skin, and Skin Firming Formulation Type: Serum Ingredient Preferences: Fragrance-Free, Hypoallergenic, Non-Comedogenic, Paraben-Free, Phthalate-Free, and Sulfate-Free Ingredients: Deionized water, Niacinamide, Aloe Barbadensis Leaf Juice, Chamomilla Recutita (Matricaria) Flower Extract, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Lactobacillus/Ganoderma Lucidum (Reishi Mushroom) Extract /Lentinus Edodes (Shitake Mushroom) Extract Ferment Filtrate, Glycerin, Royal Jelly, Copper Tripeptide-1, Lactococcus Ferment Lysate, Saccharomyces/Capsicum Annuum Fruit Ferment Filtrate, Lactobacillus Ferment Lysate, Hydrolyzed Ganoderma Lucidum (Mushroom) Extract, Sodium Hyaluronate, Beta-Glucan, Centella Asiatica Extract, Fructooligosaccharides, Beta Vulgaris (Beet) Root Extract, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-5, Silver dihydrogen citrate, Citric acid

Lead-induced downregulation of soluble guanylate cyclase in isolated rat aortic segments mediated by reactive oxygen species and cyclooxygenase-2
Don't expect overnight results though
Pycnogenol (French pine bark extract) was recently reported to reduce muscle pain and fatigue in people with fibromyalgia, but how strong is the evidence
Wong CW Hong Kong medical journal = Xianggang yi xue za zhi 2015