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In particular, EGFR, a tyrosine kinase receptor of the ErbB family, activates multiple downstream signaling pathways (Oda et al., 2005) such as RAS/MAPK(ERK) and PI3K/AKT/mTOR pathways that collectively promote cell proliferation and survival while inhibit apoptosis

Possible minor side effects include vein irritation or slight discomfort at the injection site

Elevated IDO/TDO activity, often assessed through the KYN/TRP ratio, leads to increased TRP metabolism via the KP at the expense of 5-HT synthesis

This supports efficient energy production and helps prevent the mitochondrial degradation associated with aging and fatigue

PubMed Central , doi:10.1161/JAHA.115.002621