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Semaglutide activates GLP-1 receptors in the hypothalamus (appetite), brainstem (fullness/nausea), pancreas (insulin), stomach (gastric emptying), and targets in the heart, liver, and kidneys

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Entero-endocrine-osseous axis : gastrointestinal hormones as substrates for DPP-4 The initial observation that patients receiving long-term parenteral nutrition develop osteoporosis and osteomalacia raised suspicion about the lack of stimulation for the secretion of incretin hormones in this mode of nutrition and a potential connection between these hormones and bone metabolism [42]

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The authors modified the GLP-1 receptors of mice with gene-editing techniques, making them more humanlike

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