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By incorporating estrous monitoring into current pre-clinical biomedical research, experimenters can assess differential effects of drugs and doses across estrous phases, which will be critical for understanding how drugs interact with endogenous fluctuations in hormonal state 72

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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Roth A., Sattelmayer M., Schorderet C., Gafner S., Allet L

For instance, research has demonstrated that the mRNA and protein expression levels of HMGB1 are notably higher in bladder cancer (BUC) tissues and cell lines compared to non-tumor cells

Estrogen-receptor-dependent regulation of neural stem cell proliferation and differentiation

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