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In an embryofetal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075, and 0.15 mg/kg twice weekly (0.4-, 2-, and 6-fold the MRHD) were administered throughout organogenesis, from Gestation Day 16 to 50

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Abstract: Depeint, F., Bruce, W

The use of a different cell type may require modification of the model, given the particular physiological characteristics of each endothelial cell type

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