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And while metformin has been the first-line therapy in treating type 2 diabetes, the FDA announced in 2019 that Rybelsus (semaglutide), a GLP-1, can also be offered as a first-line treatment

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As is typical with GLP-1 medications, weight loss was somewhat lower in the diabetes population but blood sugar control was significantly improved

Discontinued Semaglutide on Weight Maintenance (JAMA, 2022) 4.DailyMed prescribing information Wegovy (semaglutide) injection and tablets, revised June 2026 5.NIH MedlinePlus Semaglutide Injection

Longo N, Frigeni M, Pasquali M