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Start your intake How Semaglutide and Thyroid Medication Interact Semaglutide works by slowing gastric emptying and activating GLP-1 receptors in the brain and pancreas, while levothyroxine replaces thyroid hormone to restore metabolic balance

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However, because it actively lowers blood pressure and promotes mild vasodilation (relaxing of the blood vessels), it can interact with antihypertensive medications, potentially causing blood pressure to drop too low

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