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One important finding from clinical trials is that gastrointestinal side effects like nausea, vomiting, diarrhea are highly related to the medication dose and the rate the dose is increased

At maintenance doses of 2.0mg or 2.4mg, the volume increases significantly

Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1[3

A significant decrease in the renal corpuscles and glomerulus size was found in the DS group versus the control one

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Reduced insulin secretion , which may facilitate fat mobilisation