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For some carefully selected patients, that opens the door to eventually reducing the drug burden rather than escalating it: a lower biologic frequency, a smaller methotrexate dose, or getting off chronic steroids

PD is the second most common NDD and is characterized by progressive loss of dopaminergic and specific non-dopaminergic neurons and the presence of Lewy bodies, which mainly consist of abnormally aggregated -synuclein

Research shows these medications can lead to roughly 1022% average body weight loss over about one year , depending on the medication and dose

But the key finding is that orforglipron still provided dramatically better weight maintenance than stopping treatment entirely

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