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To maximize its benefits, Vitamin C should be integrated into a broader management strategy that includes aggressive pacing to prevent post-exertional malaise, diligent symptom tracking to identify specific MCAS triggers, and appropriate dysautonomia protocols like increased sodium and fluid intake

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However, it would be scientifically inappropriate to attribute this progression directly to glutathione supplementation, as these patients had advanced chronic liver disease with a natural trajectory toward decompensation, and critically, there was no control group to compare against