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In adults with obesity, without type 2 diabetes, weight loss is typically about 15-16 percent of starting body weight over the course of a year with Wegovy, Maselli says

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Lean mass plays a major role in resting metabolic rate, and resting metabolic rate strongly influences weight stability over time

doi: 10.1016/j.bodyim.2025.101890

At this point, the rate of weight loss is typically 1.5 to 2.5 pounds per week for most individuals

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