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Long-term considerations Maintenance dosing After reaching goal weight: Some continue at therapeutic dose indefinitely Others may reduce to lower maintenance dose (4-8 mg) Weight regain is common if medication is stopped Long-term studies are ongoing Duration of treatment Based on clinical trial data: Weight loss continues for at least 48-68 weeks Plateau may not occur even at 48 weeks Long-term (multi-year) data not yet available Treatment may be indefinite for weight maintenance Monitoring recommendations Regular check-ins should include: Weight and body composition Blood pressure and heart rate Blood glucose and HbA1c Lipid panel Liver and kidney function Review of symptoms and side effects Frequently asked questions What is the starting dose for retatrutide

The STEP 3 trial involved 611 adults who combined Semaglutide 2.4 mg with behavioral counseling and a low-calorie diet

Neurological symptoms such as numbness, tingling, balance problems, or cognitive changes require urgent treatment to prevent permanent complications

As patients lose fat mass, they become more metabolically healthy, reducing strain on multiple organs