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Metreleptin is a once daily subcutaneously administered leptin analogue approved by the FDA in 2014 for use in people with leptin deficiency or congenital/acquired lipodystrophy, with good clinical results in these conditions [86]

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These in vitro results demonstrated that H2O2 induces Leydig cell senescence, accompanied by FOXO4 nuclear translocation and activation of senescence pathways

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BPC-157 complements this by mitigating drug-induced nephrotoxicity and ischemia-reperfusion damage, preserving kidney function through anti-apoptotic and anti-oxidative mechanisms