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Alcoholism, malabsorption, prolonged stress, tapeworm infestation, vegan diets, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, macrobiotic diets or other restrictive diets

Include specialized mitochondrial function assessments (citrate synthase activity, mitochondrial DNA content, or high-resolution respirometry) if available to confirm NAD+-dependent mitochondrial enhancement

Consider Other Nutrient Deficiencies Low B12 levels can sometimes be linked to deficiencies in other essential nutrients, such as iron and folate

(2) Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM

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The collection can be accessed here: To view or add a comment, sign in Excited to share our recent review published in Angewandte Chemie: Chanda