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It explains why folate supplementation (particularly with 5-MTHF rather than folic acid in T/T individuals) improves endothelial function and reduces arterial stiffness in published clinical trials effects that operate partly through homocysteine lowering and partly through BH4 recycling restoration and improved eNOS coupling efficiency

doi: 10.1038/nrgastro.2015.35

doi: 10.1371/journal.pone.0074440 88

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Asn205 was suggested to be crucial for tyrosinase activity through the activation of a conserved water molecule 35,46