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Notably, patients with mutations in GGT1 often present with developmental disorders, accumulation of GSH (glutathionaemia and glutathionuria) and reduced circulating levels of cystine 25

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Consistency matters because antioxidant systems respond to steady support, not sporadic bursts

Using Reverse Transcription-quantitative Polymerase Chain Reaction (RT-qPCR), Glp1r mRNA was detected in the OB of both RD and WD-fed mice and found to be significantly increased in the latter (Fig

GLP-1RAs appear to offer a potential dual therapeutic advantage, simultaneously targeting metabolic dysfunction and immune-mediated inflammation, thereby representing a potentially promising strategy in the management of early-stage PsA early PsA, although robust clinical evidence in this setting is currently lacking

Supplementary Data 6 (download XLSX Source data for Supplementary Fig