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PARP1, the most abundant and well-characterized family member, rapidly binds to DNA breaks and consumes large quantities of NAD+ to synthesize poly(ADP-ribose) chains that serve as recruitment platforms for DNA repair proteins
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Acute dosing raises whole-body energy expenditure even in mice that lack the beta-3 adrenergic receptor, which means part of the effect runs through other pathways
Its role is centered on healing, inflammation control, and tissue repair
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