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In some embodiments, the otic formulation or composition comprises about 13% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Data from 2 independent experiments (1213 mice per group) were pooled

Cardiac metabolic memory Even when glucose level has been restored, chronic rise in glucose concentration as seen in DM stimulates metabolic alterations that modify tissue homeostasis

In some instances, particles are sized via fluid energy (e.g., by spiral jet mills, loop jet mills, and/or fluidized bed jet mills)

This includes those with conditions like pernicious anemia, certain gastrointestinal disorders, or age-related absorption issues