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Most chronic diseases of the CNS are associated with loss of function of astrocytes, and such loss of function is emerging as a leading mechanism of disorder-related neurological dysfunctions ranging from mild changes in synapse regulation to potential overt neurotoxicity in extreme cases
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Steady plasma concentrations are reached within 4-5 weeks, even at these lower doses
This is a groundbreaking result for patients. Wegovy, which is also approved for weight loss without diabetes, has twice failed to win a PBS listing, unlike its sister drug Ozempic (also semaglutide), which is subsidised for diabetes
Bezin J, Gouverneur A, Pnichon M, Mathieu C, Garrel R, Hillaire-Buys D, et al