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Increase to 5 mg: After 4 weeks, increase the dose to 5 mg once weekly

typically resolving within 1-2 days of implant placement Expected effects : Skin hyperpigmentation at implant site and systemically (expected pharmacological effect) Melanocytic monitoring : Low rates of new nevi (4% versus 2% placebo in Phase 3)

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730 FtMt protein expression is significantly upregulated in MCAO/R mice, and the absence of FtMt promotes free iron deposition and lipid peroxidation, which aggravates ferroptosis and brain injury caused by MCAO/R