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Quick Answer: Tirzepatide does slow digestion by delaying gastric emptying through its GLP-1 receptor agonist activity, causing food to move more slowly from the stomach into the small intestine

The company did notice a slightly higher rate of urinary tract infections in people on the drug compared with placebo, but most were mild and resolved while people stayed on treatment, Skovronsky said

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And I think that is actually a piece that many of my colleagues forget or they're like 150 minutes of aerobic activity a week

Resmetirom also takes advantage of hepatic first-pass extraction to achieve a liver-to-plasma exposure ratio of approximately 8:1 [16, 18]