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Dose escalations: Each time the dose increases, GI symptoms may briefly return

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In the UK, typical oral doses for dietary deficiency are 50-150 micrograms daily, with higher doses (1000-2000 micrograms) generally reserved for clinical situations under healthcare supervision

Therefore, targeting TMAO may represent a promising therapeutic strategy for the treatment of kidney diseases

Cell Death Differ 22:15021516

Compared with the NC group, animal experiments found that the serum aspartate transaminase (AST), alanine transaminase (ALT), total cholesterol (TC), and TG were increased in the HF group, and the level of liver TG was also increased