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(But) the magnitude of the benefit that you are receiving is really, really modest, he says

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Most clinical trials run 52 weeks or longer, and stopping short typically results in regaining 50% or more of lost weight within months

Three months of consistent appetite reduction and improved dietary habits produces the kind of physical transformation that other people start to notice

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Results published in the New England Journal of Medicine in May 2025 confirmed what many expected: Tirzepatide significantly outperformed Semaglutide on every measured endpoint