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In a RDP clinical trial with 200 peri-menopausal women, a significant decrease of LDL cholesterol by 9.9% and a significant increase of HDL cholesterol by 4.6% were observed after six months of Pycnogenol (200 mg) supplementation ( supplementation by 3.9 and 3.5%, respectively, while after placebo systolic and diastolic blood pressures were decreased by 1.7 and 1%, respectively

Well, thats not what I was expecting! Michael remembered thinking at the time

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The compound's ability to reverse age-related deficits in fitness, fur density, renal function, and reproductive health in animal models provides researchers with unprecedented opportunities to study the causal relationships between cellular senescence and aging phenotypes

Conversely, aged cardiovascular systems might respond differently to the peptides multiple mechanisms, and these differences remain unstudied

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