Urgency: A constant sensation of needing to urinate, often with little output
SLC22A12 gene encoding for the urate transporter hURAT1 defects leads to primary renal hypouricemia characterized by increased UA excretion from a reduced reabsorption (Tana et al., 2018)
Improved affordability is expected to enable more patients to initiate and continue therapy, supporting better disease management outcomes
Practical nausea-management strategies are the same for both drugs: eat smaller meals, avoid high-fat foods during titration, stay hydrated, and consider ondansetron 4 to 8 mg if symptoms impair daily function
Finally, although reaching a consensus was not an objective of this study, the nature of the evidence limits the results to statements
Following dehydration in ascending concentrations of ethanol solutions (5 min washes in 50%, 70%, 100%, and 100% ethanol), slides were air-dried, and a hydrophobic barrier was created around the sections using a hydrophobic pen (Vector Labs)
