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This mechanism has been validated in RCTs in populations including older adults, hemodialysis patients, and schizophrenia patients on maintenance medication

The fasting trial showed 15% less rebound eating four hours after the last dose, confirming 4-6 hour duration

Golpayegani et al

Safety & Maintenance Medical supervision is critical: TRT can affect hematocrit, prostate health, sleep apnea, and cardiovascular markers we screen and monitor