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Additionally, there was no significant change in the intensity ratio observed in the presence of GSSG, which confirms the specificity of FLIP-G with reduced form (GSH) over the oxidized one (GSSG) in vivo (Fig

TGR5 activity appears to not have been lost in type 2 diabetic humans whereby the infusion of CCK, or rectal taurocholate, causes GLP-1 and insulin release via the TGR5 axis in colonic L-cells and pancreatic -cells respectively (341, 342)

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Social media as pharmacovigilance: the potential for patient reports to inform clinical research on glucagon-like peptide 1 (GLP-1) receptor agonists for substance use disorders

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Green notes, that patient-driven curiosity is helping move medicine from reactive care toward earlier, more personalized, and more preventive approaches. Overall, 2025 demonstrated how science, technology, and medicine can work together to improve lives